The International Subarachnoid Aneurysm Trial (ISAT) demonstrated improved one-year clinical outcomes for patients with ruptured. It seems likely that the International Subarachnoid Aneurysm Trial (ISAT) will have a comparable effect on aneurysm surgery. Even before the publication of the. The recent publication of the initial data from the International Subarachnoid Aneurysm Trial (ISAT) represents a landmark in the evolution of.

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Long-term follow up continues. Role of angiography following aneurysm surgery. Treatment of intracranial aneurysms by embolization with coils.

The risk of late rebleeding is low, but is more common after endovascular coiling than after neurosurgical clipping. Although the initial ISAT analysis appeared to favor endovascular coiling over microsurgical clipping, subsequent meta-analysis have questioned that conclusion, finding higher incidences of recurrence.

Assessment of scales of disability and handicap for stroke patients. Secondary outcomes included rebleeding from the treated aneurysm and risk of seizures. Online since 20 th March ‘ Qureshi, Textbook of Interventional NeurologyEd. We undertook a randomised, multicentre trial to compare these treatments in patients who were suitable for either treatment because the relative safety and efficacy of these approaches had not been established. Coils or abeurysm in subarachnoid haemorrhage?

What percentage of surgically clipped aneurysms have residual necks?

The study found better results with endovascular coil treatment compared to surgical ameurysm, however subsequent studies have questioned this conclusion. The first results were published in The Lancet inand the 10 year data were published again in The Lancet in early September The International Subarachnoid Aneurysm Trial ISAT was a large multicentre, prospective randomised clinical medical trialcomparing the safety and efficacy of endovascular coil treatment and surgical clipping for the treatment of brain aneurysms.


Isaat S, Kreiter K.

By using this site, you agree to the Terms of Use and Privacy Policy. Could late rebleeding overturn the superiority of cranial aneurysm coil embolization over clip ligation seen in ISAT?

International Subarachnoid Aneurysm Trial

Scott Med J ;2: The risk of epilepsy was substantially lower in patients allocated to endovascular treatment, but the risk of late rebleeding was higher. We report aneurym 1-year outcomes for of patients allocated to endovascular treatment, and of patients allocated to neurosurgical treatment. Analysis was in accordance with the aneurym treatment. International subarachnoid aneurysm trial ISAT of neurosurgical clipping versus endovascular coiling in patients with ruptured intracranial aneurysms: Updated data from the ISAT group in March shows that the higher aneurysm rate of recurrence is also associated with a higher rebleeding rate, given that the rebleed rate of coiled aneurysms appears to be 8 times higher than that of clipping treated aneurysms in this study.

International Subarachnoid Aneurysm Trial – Wikipedia

This page was last edited on 13 Decemberat Iat ISAT trial [letter]. J Neurol Neurosurg Psychiatry ; Risk of aneurysm recurrence in patients with clipped cerebral aneurysms.


Georgiadis, Cambridge University Press: The impact of the international subarachnoid aneurysm trial ISAT on neurosurgical practice. Published by Wolters Kluwer – Medknow.

In patients with ruptured intracranial aneurysms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival benefit continues for at least 7 years. Alexander, Robert Friedrich Spetzler, Pediatric neurovascular disease: Br J Neurosurg ; Click on image for details.

Two types of treatment are being used for patients with ruptured intracranial aneurysms: Natural history of the neck remnant of a cerebral aneurysm treated with the Guglielmi detachable coil system.

It appears that although endovascular coiling is associated with a shorter recovery period as compared to surgical clipping, it is also associated with a significantly higher recurrence rate after treatment. The primary outcome was death or dependence at 1 year defined by a modified Rankin scale anekrysm The long-term data for unruptured aneurysms are still being gathered.

Lessons to be learnt from the international subarachnoid haemorrhage isar ISAT. Results of direct surgery for aneurismal subarachnoid hemorrhage: Sade B, Mohr G.

Views Read Edit View history. Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils.