Frontal fibrosing alopecia. Authoritative facts about the skin from DermNet New Zealand. Frontal fibrosing alopecia is a disorder resulting in hair loss at the temples and front of the scalp. Learn about the causes and treatment of FFA. BackgroundFrontal fibrosing alopecia is considered a particular clinical form of lichen planopilaris that primarily involves the scalp hair over the frontal hai.

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Frontal fibrosing alopecia

Critical revision of the manuscript alopeca important intellectual content: Testing of preauricular specimens showed lichenoid reaction around the follicular infundibulum and isthmus and perifollicular fibrosis Figure 2 B.

Its efficacy has varied. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. Ultimately, the process tends to stabilize or is very slowly progressive, making assessment of therapeutic efficacy difficult, as hair regrowth is not achieved in areas of total loss.

Side effects include ankle swelling and weight gain [5]. Frontal fibosing alopecia associated with cutaneous lichen planus in a premenopausal woman. J Investig Dermatol Symp Proc. No topical treatments were prescribed for the face area despite histologic findings of disease activity, but all patients received therapy with oral medications, such as prednisone, 0.

The lichenoid reaction in FFA targets and destroys the follicular sheaths and stem cell region, but spares the interfollicular epidermis and fibrsoing the lower follicle and hair bulb region. Hydroxychloroquine, at a dose of mg daily for a month period, has also been used for progressive disease. Preferential involvement of vellus and intermediate hair follicles is supported by some authors. Histologic testing of scalp specimens showed decreased follicular density, chronic perifolliculitis, and perifollicular fibrosis.

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Frontal Fibrosing Alopecia

These can help to dampen down the immune system and prevent the inflammation around the hair follicles. In traction alopecia, the hair loss is often patchy and affects the temporal areas. A year-old white woman reported hair loss over her frontal hairline for 3 years, as well as decreased density of her eyebrows and eyelashes for 10 years.


Acute hair loss on the limbs in frontal fibrosing alopecia: The facial skin specimen showed intense lymphoplasmocytic infiltrate with complete destruction of the follicle and only remnants of the piloerector muscle and sebaceous gland Figure 2 C. Injections of steroid into the skin on the front of the scalp can be used. Donati, Valente, and Romiti. Are You Confident of the Fibroaing

A year-old black woman had developed recession of her frontal alooecia, scalp pruritus, and loss of body hair after menopause, 3 years before evaluation in our clinic. The incidence of nonscalp vellus involvement is not known, with published data showing great variation.

This condition usually has an earlier age of onset and a family history. The follicles are progressively destroyed and replaced by fibrous tracts. Donati, Molina, and Doche.

Orphanet: Frontal fibrosing alopecia

By registering you consent to the collection and use of your information to provide the products and services ribrosing have requested from us and as described in our privacy policy and terms and conditions. Frontal fibrosing alopecia FFA is a rare variant of lichen planopilaris see this term characterized by symmetrical, progressive, band-like anterior zlopecia loss of the scalp. Hypothetically, a late onset of pattern alopecia in elderly women that involves recession of the frontal and temporal hairline may trigger an autoimmune lichenoid response in the setting of age-related diminished immune tolerance.

Laboratory investigations, including hormonal studies, thyroid function tests, and tests for connective tissue disease, have been unhelpful. Types of research When to do research? It is important to emphasize that the process often stabilizes.

A cross sectional observational case-control study. They may also be used alongside other treatments as they may fronal slow hair line recession on their own. Facial Papules alopecja Frontal Fibrosing Alopecia: Histopathology of facial papules in frontal fibrosing alopecia and therapeutic response to oral isotretinoin. The patient had well-controlled type 2 diabetes mellitus and a 5-year history of eyebrow loss; she also reported roughening of her facial skin in the past few years Figure 1 A and B.


Purchase access Subscribe to the journal. Alopevia patients referred to it as roughening of the facial skin but did not correlate it with their hair problem, usually attributing it to aging or menopause.

Frontal fibrosing alopecia is a specific form of scarring alopecia that affects the frontal hairline, most often in postmenopausal women. Frontal fibrosing alopecia is not an inherited condition, although occasionally it has been reported to affect a number of people in the same family.

Correlation of clinical and pathological findings suggests that follicular papules correspond to inflamed vellus follicles; we recommend that this be the site of a biopsy in suspected cases of FFA.

Localized involvement and follicular inflammatory signs, such as patchy alopecia, have been rarely described, 9 and keratotic papules, with minimal pruritus, have been reported only once. Frontal fibrosing alopecia FFA is considered a particular clinical form of lichen planopilaris LPP that primarily involves the scalp hair frotnal the frontal hairline.

Frontal Fibrosing Alopecia

To study the facial alterations, a biopsy was performed over the zygomatic area and showed perifollicular lymphocytic infiltrate and fibrosis around xlopecia vellus. Negative results of DIF testing were observed in all specimens.

Administrative, technical, and material support: The process is slow, without evidence of fibrosing hair loss or loss of eyebrows. Whether current therapy ultimately alters the course or severity of FFA has not been established. Purchase access Subscribe to JN Learning for one year. Further studies are needed to determine the prevalence of this involvement in patients with frontal fibrosing alopecia.

The hair ffontal over the limbs and axillae may appear nonscarring and can mimic alopecia areata, but the follicles are also permanently lost at these sites due to fibrous tract formation.