PDF | Microsponge is novel drug delivery system formulated for topical and/or oral administration. Microsponges are po-rous microspheres. The microsponges formulations were prepared by quasi-emulsion solvent . was to formulate, optimize and evaluate Prednisolone-loaded microsponges for. Formulation and evaluation of gel-loaded microsponges of diclofenac sodium for topical delivery. Hamid Hussain, Archana Dhyani, Divya Juyal.

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Formulation and evaluation of curcumin microsponges for oral and topical drug delivery

Int J Pharm Res ; 2 1 In the present study, the different nature of the curves obtained for zero-order, first order, and Higuchi model and as demonstrated by very close and highest r squared values suggests that the release from the formulation may follow any one of these models. Probably in high drug-polymer ratios less polymer amounts surround the drug and reducing the thickness of polymer wall and microsponges with smaller size were obtained.

The samples were analyzed at the time interval of 7 days for one month. The drug release profile data were found to be fitted best into the zero-order model with anomalous transport mechanism of drug release in both cases.

Formulation and evaluation of curcumin microsponges for oral and topical drug delivery

Afrasim MoinTamal K. Microsponges are in porous nature so provide better controlled release and sufficient dose to the colon.

On the basis of maximum regression value, zero order was found to be the best fit model for evaluafion of the formulations microspomges Table 3 ]. Mcirosponges particle size and size distribution of the prepared microsponges was determined by using optical microscopy method.

The in-vitro dissolution studies of microsponges in the media with different pH 1. All other chemicals were of reagent grades and used as procured. Water was given ad libitum during fasting and throughout the experiment.


Drug-excipient interaction study Compatibility study was carried out to check for any possible interaction between drug and excipients used. The average weight of capsule formulations was found to be within pharmacopoeial limit. The topical formulation must exhibit acceptable mechanical characteristics such as low hardness and high adhesiveness.

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X-ray diffraction patterns of a fluconazole and b microsponge formulation. The cumulative amount released increased with an increase in concentration of active ingredient in the formula. The drug release study for gel containing pure, unentrapped FLZ marketed formulation, F11 was carried out and release profile obtained was as depicted in Figure 5c.

Liposomal delivery enhances cutaneous availability of ciclopiroxolamine.

The result was shown in table. Preparation and in-vitro evaluation of modified release ketoprofen microsponges. Spreadability is used to express the extent of the area of skin or affected part to which gel readily spreads. Microsponges can be prepared by two methods known as liquid- liquid suspension polymerisation method and quasi-emulsion solvent method. Int J Pharm; By infrared spectroscopic study, identity and purity of the drug was confirmed and it was cleared that there was no significant barriers to the development of the proposed formulation of the drug with the polymer and excipients.

The estimated drug remained in the skin was Top J Pharm Res. The findings of spreadability depicted that formulated gel get easily spread on applying small amount of shear.

Microsponges based novel drug delivery system for augmented arthritis therapy. In first group no drug or formulation was given. Prepared gels were packed in wide mouth glass jar covered microspoges screw capped plastic lid after covering the mouth with aluminum foil and were kept in dark and cool place until use.


An in-vitro drug release study was carried out in United States Pharmacopoeia USP dissolution testing apparatus 2 Paddle type using treated dialysis membrane. The materials required for the present work were procured from diverse sources. The total drug content and entrapment of the drug depend on the formulztion molecular association of the drug with the polymers.

It was observed that the microsponges were formhlation, and uniform with no drug crystals on surface. Further, release data was analyzed using diverse mathematical models to know release kinetics. The advantage of MDS includes the programmable release of drug and biological safety of the system.

It was observed that on increasing the concentration of emulsifier, microsponges of large irregular shape was formed as seen by optical microscopy due to the increased viscosity. Evaluation of the kinetics and mechanism of drug release from econazole nitrate nanosponge loaded carbapol hydrogel.

The reason of this may be that the polymer employed was non-ionic and molecule can associate away from oil-water interface at higher concentrations. Application of different kinetic models for in vitro drug release: In order to simulate the pH changes along the GI tract, three dissolution media with pH 1.

Conclusion The objective of developing polymeric microsponge delivery system was to deliver curcumin in a sustained manner for an extended period of time, to reduce frequency of administration and to improve its bioavailability.