Hepatocellular carcinoma is a tumor with a high incidence and high mortality. These data .. manejo del CHC celebrada en Barcelona en el an˜o definieron por vez primera .. hepática (clasificación Child-Pugh) y presencia de sıntomas. The present manuscript depicts the Barcelona‐Clínic Liver Cancer Group diagnostic and treatment strategy. This is based on the analysis of. The value of the Barcelona Clinic Liver Cancer and alpha-fetoprotein in the Conclusiones: nuestros resultados confirman que la clasificación BCLC es un.

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These figures have also been recently reproduced when analysing survival estimates gathered from population-based cancer registries Natural history of untreated nonsurgical hepatocellular carcinoma: The current knowledge of the disease, however, prevents recommendation of a staging system that can be used world-wide.

Barceelona these cases, it is assumed that therapies actively modify the natural course of the disease.

Only patients managed by specialized practitioners in HCC from our department were included. Increased survival of cirrhotic patients with hepatocarcinomq hepatocellular carcinoma detected during surveillance.

Similarly, advanced tumors in Child-Pugh C patients also account for a very poor prognosis. These populations harbor dysplastic hepatocytes as a result of altered gene expression, telomerase erosions and even chromosome aberrations. The mean age of the patients was The value of the Barcelona Clinic Liver Cancer and alpha-fetoprotein in the prognosis of hepatocellular carcinoma.

The median survival among each group was: BCLC 4 A recent comparison with other staging systems has claskficacion that it has limited prognostic capacity in patients with early HCC As such, it is necessary to improve the prediction of the prognosis of these patients in order to properly identify clasiticacion potential candidates for therapy and to critically evaluate the results of hepatoczrcinoma treatment modalities.


In Spain an important proportion of patients at risk of HCC are not in a surveillance program 11which is due to a lack of strict compliance with the same, as well as not knowing of the existence of underlying liver cirrhosis in those patients with asymptomatic live disease.

However, in some studies AFP was associated with survival 15,16 and can help to identify subsets of HCC patients with increased risk for early recurrence and poor prognosis after hepatectomy 17 or transplant 18but its value has not been properly defined.

This article hepatocarcjnoma been cited by other articles in PMC.

Staging systems in hepatocellular carcinoma

Seminar in Liver Disease ; Analysis of 5, cases from a medical center in southern Taiwan. They use rough descriptions of tumor stage that are not in accordance with the predictive value of tumor size and multicentricity.

Our current level of knowledge prevents recommendation of a staging system to be used worldwide. Barber, 30 Toledo, Spain e-mail: The aim of this study was to evaluate the BCLC classification in our clinical practice and to know what the prognostic value of AFP is.

There is only one prospective trial globally validating the BCLC system Natural history of untreated nonsurgical hepatocellular carcinoma: Liver Cancer Study Group of Japan. First, HCC is a complex neoplasm inserted on a pre-neoplastic cirrhotic liver, and thus variables of both diseases leading to death should be taken into account.

Staging systems in hepatocellular carcinoma

Comparison of staging systems for HCC. Prevalence and prognostic value of hepatocellular carcinoma in cirrhotic patients with spontaneous bacterial peritonitis. Three dd with a single nodule greater than 8 cm were classified as stage B because we considered that they had a multinodular tumor.

However, this system is useful for identifying only end-stage patients, and provides no valid discrimination for less advanced patients. Some studies found that HCC patients with high AFP tended to have greater tumor size, bilobar involvement, massive or diffuse types, and portal vein thrombosis, and equally, AFP was a prognostic indicator Whether the patient was treated or not was included in the model as in some cases patients could not be treated according the BCLC system no options o rejected treatment.


More recently, new systems have appeared, suggesting a stronger discriminatory power when compared with published ones An increased incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake 5which are major risk factors for HCC 2,6.

Natural history of hepatocellular carcinoma and prognosis in relation to treatment. It lacks external validation in Barce,ona countries. Liver transplantation for treatment of small hepatocellular carcinoma: Many studies have reported variable survival in HCC patients.

This proposal is not a scoring system as it derives from the identification of independent prognostic factors in the setting of several studies, conforming a staging classification. Finally, once diagnosis is established, the prognosis hepatodarcinoma patients will vary according to the evolutionary stage at which the neoplasm is diagnosed and the treatment received.

Survival of HCC patients has improved because of the advancement of the time hepatocrcinoma diagnosis and the increase in therapeutic efficacy. Our surveillance program is hepqtocarcinoma on ultrasound performed every 6 months. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma.

Currently alpha fetoprotein AFP is considered an inadequate screening or diagnostic test for HCC because of poor sensitivity and specificity. Trends in survival of patients with hepatocellular carcinoma between and in United States